Weitz Group @ Georgia Tech Theoretical Ecology and Quantitative Biology

Metagenomic binning article published in BMC Bioinformatics

Posted by kislyuk

An article by members of the Weitz group titled "Unsupervised statistical clustering of environmental shotgun sequences" has been publised in BMC Bioinformatics. The article is available at http://www.biomedcentral.com/1471-2105/10/316. The full citation is as follows:

Andrey Kislyuk, Srijak Bhatnagar, Jonathan Dushoff and Joshua S Weitz. Unsupervised statistical clustering of environmental shotgun sequences. BMC Bioinformatics 2009, 10:316. doi:10.1186/1471-2105-10-316

The paper describes a new method for binning metagenomic fragments, that is, classifying shotgun sequenced fragments of environmental DNA according to their origin, with a focus on low complexity communities. The unsupervised nature of this algorithm allows it to work on mixtures of DNA without regard to how many sequenced relatives of constituent bacteria are available, complementing existing algorithms for metagenomic binning that rely on supervised and semi-supervised approaches.